THE DEFINITIVE GUIDE TO TRASTUZUMAB DOSING

The phosphorylated HER3 supplies docking web-sites for p85 subunit of PI3K. The absolutely activated PI3K complex is produced by binding of p110 subunit of PI3K to p85 which will be able to produce PIP3 via phosphorylating the PIP2. AKT binds to PIP3 and is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at the two threonine and serin pho